17-AAG (CAS 75747-14-7) from LIFESPAN BIOSCIENCES INC.

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Product Name17-AAG (CAS 75747-14-7)
DescriptionGlendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG. 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin and UCN-01 (400 nM 17-AAG, U937 cells). Purity >98%
Size1 mg, 5 mg
Concentrationn/a
Applicationsn/a
Other Namesn/a
Gene, Accession, CAS #CAS: 75747-14-7
Catalog #LS-H1652
Priceplease inquire
Order / More Info17-AAG (CAS 75747-14-7) from LIFESPAN BIOSCIENCES INC.
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LIFESPAN BIOSCIENCES INC.
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