AAL-993 (CAS 269390-77-4) from LIFESPAN BIOSCIENCES INC.

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Product NameAAL-993 (CAS 269390-77-4)
DescriptionAAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM) and VEGFR-3 (IC50 = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model). Purity >98% by TLC
Size10 mg, 2 mg
Concentrationn/a
Applicationsn/a
Other Names2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide
Gene, Accession, CAS #CAS: 269390-77-4
Catalog #LS-H3287
Priceplease inquire
Order / More InfoAAL-993 (CAS 269390-77-4) from LIFESPAN BIOSCIENCES INC.
Product Specific Referencesn/a
LIFESPAN BIOSCIENCES INC.
LIFESPAN BIOSCIENCES INC.
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