Sca-1 Antibody Kit, anti-mouse, FITC, REAlease® from MILTENYI BIOTEC B.V. & Co. KG
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| Product Name | Sca-1 Antibody Kit, anti-mouse, FITC, REAlease® |
| Description | Sca-1 Antibody Kit, anti-mouse, FITC, REAlease®. Clone REAL175 is an antibody fragment derived from the full Sca-1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REAL175 recognizes the mouse stem cell antigen-1 (Sca-1) antigen, an 18 kDa glycosylphosphatidylinositol (GPI) linked protein which is also known as lymphocyte antigen 6A and 6E (Ly-6A/E). Clone REAL175 specifically recognizes both Ly-6E.1 and Ly-6A.2, which are gene products of the two Ly-6A/E alleles expressed in different mouse strains (Ly-6E.1: e.g. BALB/c, C3H, NZB; Ly-6A.2: e.g. C57BL/6, SJL, 129, AKR). Sca-1 is expressed on hematopoietic stem cells and progenitor cells in mouse bone marrow and is one of the defining markers for so-called KSL (c-kit+ Sca-1+ Lin-) cells. In combination with CD105 (Endoglin) expression, Sca-1 has been used to define long-term repopulating hematopoietic stem cells (LTR-HSCs) in mouse bone marrow. In addition, Sca-1+ bone marrow cells also contain the mesenchymal stem cell fraction. Sca-1+ cells have been shown to give rise to hepatocytes in vivo and neural cells in vitro. Furthermore, Sca-1 is expressed on stem cells in a variety of nonhematopoietic tissues, such as adult liver, heart, and prostate. | The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes. |
| Size | 100 tests |
| Concentration | 1:50 |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Other Names | LY6A, Ly-6A.2, Ly-6A/E, Ly-6E.1, TAP |
| Gene, Accession, CAS # | n/a |
| Catalog # | 130-122-615 |
| Price | $117 |
| Order / More Info | Sca-1 Antibody Kit, anti-mouse, FITC, REAlease® from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Khan, K. D. et al. (1990) Characterization of promoter elements of an interferon-inducible Ly-6E/A differentiation antigen, which is expressed on activated T cells and hematopoietic stem cells. Mol. Cell. Biol. 10 (10): 5150-5159. | Bradfute, S. B. et al. (2005) Roles of Sca-1 in hematopoietic stem/progenitor cell function. Exp. Hematol. 33 (7): 836-843. | Houlihan, D. D. et al. (2012) Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-α. Nat. Protoc. 7 (12): 2103-2111. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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