CD53 Antibody Kit, anti-human, APC, REAlease® from MILTENYI BIOTEC B.V. & Co. KG

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Product NameCD53 Antibody Kit, anti-human, APC, REAlease®
DescriptionCD53 Antibody Kit, anti-human, APC, REAlease®. Clone REAL144 is an antibody fragment derived from the full CD53 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REAL144 recognizes the CD53 antigen, a 35-42 kDa type II transmembrane glycoprotein which is also known as tetraspanin-25. CD53 is expressed on all leukocytes, including plasma cells, but not on platelets, erythrocytes, and non-hematopoietic tissues. CD53 mediates oxidative burst in monocytes and has been shown to interact with a number of proteins including interleukin 4 (IL-4), CD20, CD2, CD9, IL-2, VLA-4, and CD4. Cross-linking of CD53 on monocytes induces a strong increase in intracellular calcium ions, whereas a modest increase is seen in B lymphocytes. In resting B cells, the molecule transmits a co-stimulatory signal and promotes activation through the Ig receptor. | The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes. |
Size100 tests
Concentration1:50
Applications, Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence
Other NamesMOX44, TSPAN25
Gene, Accession, CAS #n/a
Catalog #130-122-707
Price$440
Order / More InfoCD53 Antibody Kit, anti-human, APC, REAlease® from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesAngelisova, P. et al. (1990) The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. Immunogenetics 32 (4): 281-285. | Maecker, H. T, et al. (1997) The tetraspanin superfamily: molecular facilitators. FASEB J. 11: 428-442. | Olweus, J. et al. (1993) CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells. J Immunol 151: 707-716.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

macs@miltenyibiotec.de

https://www.miltenyibiotec.com

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