ABT-888 (Veliparib) from MYBIOSOURCE INC.
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| Product Name | ABT-888 (Veliparib) |
| Description | Purity >99%. ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.The compound has good oral bioavailability and crosses the blood-brain barrier. ABT-888 strongly potentiated temozolomide in the B16F10 s.c. murine melanoma model. In the MX-1 breast xenograft model(BRCA1 deletion and BRCA2 mutation), ABT-888 potentiated cisplatin, carboplatin, and cyclophosphamide, causing regression of established tumors, whereas with comparable doses of cytotoxic agents alone, only modest tumor inhibition was exhibited[1]. A significant correlation exists between MRE11 expression levels and cytotoxicity to ABT-888 at 10 uM (R2=0.915, P<0.001).[2] ABT-888 was toxic to both oxic and hypo. MW: 244.29 |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | n/a |
| Gene, Accession, CAS # | [ABT-888] |
| Catalog # | MBS8506523 |
| Price | $265 |
| Order / More Info | ABT-888 (Veliparib) from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.