Human CXCL10 (IP-10) from MYBIOSOURCE INC.
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| Product Name | Human CXCL10 (IP-10) |
| Description | Sequence: 22-98. Purity > 97% by SDS PAGE. CXCL10 (IP-10) was originally identified as an IFN-gamma-inducible gene in endothelial, fibroblasts and monocytes cells. IP-10 is considered a member of the CXC chemokine subfamily from its protein sequence which includes the four conserved cysteine residues present in CXC chemokines. IP-10 signals through the CXCR3 receptor to selectively attract Th1 lymphocytes and monocytes. It also has angiostatic and mitogenic properties on vascular smooth muscle cells. A diverse population of cell types rapidly increases transcription of mRNA encoding IP-10, which suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response. Actual Molecular Mass: Mass Spec data confirmed expected mass of 8.6kDa. Predicted Molecular Mass: 8.6 kDa |
| Size | 0.005 mg, 0.02 mg, 0.05 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | [CXCL10 (IP-10)], [CXCL10; CXCL10; C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; INP10; SCYB10; Gamma-IP10; IP-10] |
| Gene, Accession, CAS # | [CXCL10], Gene ID: 3627, NCBI: NP_001556.2, UniProt: P02778 |
| Catalog # | MBS444022 |
| Price | $115, $170, $280 |
| Order / More Info | Human CXCL10 (IP-10) from MYBIOSOURCE INC. |
| Product Specific References | 1. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Luster A.D., Unkeless J.C., Ravetch J.V. Nature 315:672-676(1985)2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project Team Genome Res. 14:2121-2127(2004)3. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J. J. Immunol. 150:1000-1010(1993)4. Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R. J. Invest. Dermatol. 112:716-722(1999)5. Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity. Hensbergen P.J., van der Raaij-Helmer E.M.H., Dijkman R., van der Schors R.C., Werner-Felmayer G., Boorsma D.M., Scheper R.J., Willemze R., Tensen C.P. Eur. J. Biochem. 268:4992-4999(2001)6. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Loos T., Mortier A., Gouwy M., Ronsse I., Put W., Lenaerts J.P., Van Damme J., Proost P. Blood 112:2648-2656(2008)7. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Booth V., Keizer D.W., Kamphuis M.B., Clark-Lewis I., Sykes B.D. Biochemistry 41:10418-10425(2002) |
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