ABT-263 (Navitoclax) from MYBIOSOURCE INC.
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| Product Name | ABT-263 (Navitoclax) |
| Description | Purity >97%. Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. Binding affinities were determined with competitive fluorescence polarization assays and a time-resolved fluorescence resonance energy transfer assay (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). The oral bioavailability of ABT-263 in preclinical animal models is 20% to 50%, depending on formulation.[1]A wide range of SCLC cellular activity was observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nmol/L against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) resulted in an EC50 at 22 mumol/L. In all cell lines w. MW: 974.61 |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | n/a |
| Gene, Accession, CAS # | [ABT-263] |
| Catalog # | MBS8506188 |
| Price | $410 |
| Order / More Info | ABT-263 (Navitoclax) from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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