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Product Name | Recombinant Human X-ray repair cross-complementing protein 6 |
Description | Sequence: 6-222aa; Partial. Purity >90% as determined by SDS-PAGE. Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing th together. The. MW: 28.9kD |
Size | 0.01 mg, 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | [5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6], [XRCC6; XRCC6; ML8; KU70; TLAA; CTC75; CTCBF; G22P1; G22P1; 5'-dRP lyase Ku70; CTC75; CTCBF; Ku70; TLAA] |
Gene, Accession, CAS # | [XRCC6/G22P1], Gene ID: 2547, NCBI: NP_001275905.1, UniProt: P12956 |
Catalog # | MBS1265152 |
Price | $160, $200, $295 |
Order / More Info | Recombinant Human X-ray repair cross-complementing protein 6 from MYBIOSOURCE INC. |
Product Specific References | Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.Chan J.Y., Lerman M.I., Prabhakar B.S., Isozaki O., Santisteban P., Kuppers R.C., Oates E.L., Notkins A.L., Kohn L.D.J. Biol. Chem. 264:3651-3654(1989) |