DPH2, 1-489aa, Human, His-tag, Baculovirus from MYBIOSOURCE INC.
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| Product Name | DPH2, 1-489aa, Human, His-tag, Baculovirus |
| Description | Purity > 85% by SDS-PAGE. DPH2, also known as diphthamide biosynthesis protein 2, is a homodimer and each of its monomers can bind a [4Fe-4S] cluster. It is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE). It was identified by its ability to complement a diphthamide mutant strain, and thus functions in diphthamide biosynthesis. Its loss pre-activates NF-kB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Recombinant human DPH2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. MW: 53.1kDa (497aa) 50-70kDa (SDS-PAGE under reducing conditions) |
| Size | 0.01 mg, 0.05 mg |
| Concentration | 0.5 mg/ml (determined by Absorbance at 280nm) |
| Applications | SDS-PAGE |
| Other Names | [Diphthamide biosynthesis protein 2; DPH2; DPH2L2], [DPH2; DPH2; DPH2L2; DPH2L2] |
| Gene, Accession, CAS # | [DPH2], Gene ID: 1802, NCBI: NP_001375, UniProt: Q9BQC3 |
| Catalog # | MBS206632 |
| Price | $310, $925 |
| Order / More Info | DPH2, 1-489aa, Human, His-tag, Baculovirus from MYBIOSOURCE INC. |
| Product Specific References | Zhang Y., et al. (2010) Nature. 465:891-896.; Mattheakis LC., et al. (1993) Gene. 132:149-154. |
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