Recombinant Human DNA repair protein complementing XP-C cells from MYBIOSOURCE INC.
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| Product Name | Recombinant Human DNA repair protein complementing XP-C cells |
| Description | Sequence: 496-734aa; Partial. Purity >90% as determined by SDS-PAGE. Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent t. MW: 31.6kD |
| Size | 0.01 mg (E. coli), 0.05 mg (E. coli), 0.1 mg (E. coli) |
| Concentration | n/a |
| Applications | n/a |
| Other Names | [Xeroderma pigmentosum group C-complementing proteinp125], [XPC; XPC; XP3; RAD4; XPCC; p125; XPCC] |
| Gene, Accession, CAS # | [XPC], Gene ID: 7508, NCBI: NP_004619.3, UniProt: Q01831 |
| Catalog # | MBS960949 |
| Price | $160, $200, $295 |
| Order / More Info | Recombinant Human DNA repair protein complementing XP-C cells from MYBIOSOURCE INC. |
| Product Specific References | Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.Masutani C., Sugasawa K., Yanagisawa J., Sonoyama T., Ui M., Enomoto T., Takio K., Tanaka K., van der Spek P.J., Bootsma D., Hoeijmakers J.H.J., Hanaoka F.EMBO J. 13:1831-1843(1994) The human XPC DNA repair genearrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function.Khan S.G., Muniz-Medina V., Shahlavi T., Baker C.C., Inui H., Ueda T., Emmert S., Schneider T.D., Kraemer K.H.Nucleic Acids Res. 30:3624-3631(2002) Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J., Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.Nat. 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Expression cloning of a human DNA repair gene involved in Xeroderma pigmentosum group C.Legerski R.J., Peterson C.A.Nature 359:70-73(1992) ErratumLegerski R.J., Peterson C.A.Nature 360:610-610(1992) XPC and human homologs of RAD23intracellular localization and relationship to other nucleotide excision repair complexes.van der Spek P.J., Eker A., Rademakers S., Visser C., Sugasawa K., Masutani C., Hanaoka F., Bootsma D., Hoeijmakers J.H.Nucleic Acids Res. 24:2551-2559(1996) Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.Sugasawa K., Ng J.M., Masutani C., Maekawa T., Uchida A., van der Spek P.J., Eker A.P., Rademakers S., Visser C., Aboussekhra A., Wood R.D., Hanaoka F., Bootsma D., Hoeijmakers J.H.Mol. Cell. Biol. 17:6924-6931(1997) Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.Sugasawa K., Ng J.M., Masutani C., Iwai S., van der Spek P.J., Eker A.P., Hanaoka F., Bootsma D., Hoeijmakers J.H.Mol. Cell 2:223-232(1998) The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.Yokoi M., Masutani C., Maekawa T., Sugasawa K., Ohkuma Y., Hanaoka F.J. Biol. Chem. 275:9870-9875(2000) Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.Batty D., Rapic'-Otrin V., Levine A.S., Wood R.D.J. Mol. Biol. 300:275-290(2000) Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.Araki M., Masutani C., Takemura M., Uchida A., Sugasawa K., Kondoh J., Ohkuma Y., Hanaoka F.J. Biol. Chem. 276:18665-18672(2001) A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex.Sugasawa K., Shimizu Y., Iwai S., Hanaoka F.DNA Repair 1:95-107(2002) The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH.Uchida A., Sugasawa K., Masutani C., Dohmae N., Araki M., Yokoi M., Ohkuma Y., Hanaoka F.DNA Repair 1:449-461(2002) DNA bending by the human damage recognition complex XPC-HR23B.Janicijevic A., Sugasawa K., Shimizu Y., Hanaoka F., Wijgers N., Djurica M., Hoeijmakers J.H., Wyman C.DNA Repair 2:325-336(2003) Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.Shimizu Y., Iwai S., Hanaoka F., Sugasawa K.EMBO J. 22:164-173(2003) UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.Sugasawa K., Okuda Y., Saijo M., Nishi R., Matsuda N., Chu G., Mori T., Iwai S., Tanaka K., Tanaka K., Hanaoka F.Cell 121:387-400(2005) Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.Nishi R., Okuda Y., Watanabe E., Mori T., Iwai S., Masutani C., Sugasawa K., Hanaoka F.Mol. Cell. Biol. 25:5664-5674(2005) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.Cell 127:635-648(2006) Toward a global characterization of the phosphoproteome in prostate cancer cellsidentification of phosphoproteins in the LNCaP cell line.Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.Electrophoresis 28:2027-2034(2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.Science 316:1160-1166(2007) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. IIIJ. Proteome Res. 7:1346-1351(2008) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.Proteomics 8:1346-1361(2008) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.Sci. Signal. 4:RS3-RS3(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation.Yasuda G., Nishi R., Watanabe E., Mori T., Iwai S., Orioli D., Stefanini M., Hanaoka F., Sugasawa K.Mol. Cell. Biol. 27:6606-6614(2007) An aromatic sensor with aversion to damaged strands confers versatility to DNA repair.Maillard O., Solyom S., Naegeli H.PLoS Biol. 5:E79-E79(2007) Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC.Hoogstraten D., Bergink S., Ng J.M., Verbiest V.H., Luijsterburg M.S., Geverts B., Raams A., Dinant C., Hoeijmakers J.H., Vermeulen W., Houtsmuller A.B.J. Cell Sci. 121:2850-2859(2008) ErratumHoogstraten D., Bergink S., Ng J.M., Verbiest V.H., Luijsterburg M.S., Geverts B., Raams A., Dinant C., Hoeijmakers J.H., Vermeulen W., Houtsmuller A.B.J. Cell Sci. 121:2972-2972(2008)ErratumHoogstraten D., Bergink S., Ng J.M., Verbiest V.H., Luijsterburg M.S., Geverts B., Raams A., Dinant C., Hoeijmakers J.H., Vermeulen W., Houtsmuller A.B.J. Cell Sci. 121:3991-3991(2008)Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein.Camenisch U., Trautlein D., Clement F.C., Fei J., Leitenstorfer A., Ferrando-May E., Naegeli H.EMBO J. 28:2387-2399(2009) Two-step recognition of DNA damage for mammalian nucleotide excision repairDirectional binding of the XPC complex and DNA strand scanning.Sugasawa K., Akagi J., Nishi R., Iwai S., Hanaoka F.Mol. Cell 36:642-653(2009) Dissection of the xeroderma pigmentosum group C protein function by site-directed mutagenesis.Clement F.C., Kaczmarek N., Mathieu N., Tomas M., Leitenstorfer A., Ferrando-May E., Naegeli H.Antioxid. Redox Signal. 14:2479-2490(2011) Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct.Neher T.M., Rechkunova N.I., Lavrik O.I., Turchi J.J.Biochemistry 49:669-678(2010) Stimulation of DNA glycosylase activities by XPC Protein ComplexRoles of protein-protein interactions.Shimizu Y., Uchimura Y., Dohmae N., Saitoh H., Hanaoka F., Sugasawa K.J. Nucleic Acids 2010:455-459(2010) Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.Yang A., Miron S., Mouawad L., Duchambon P., Blouquit Y., Craescu C.T.Biochemistry 45:3653-3663(2006) The structure of the human centrin 2-xeroderma pigmentosum group C protein complex.Thompson J.R., Ryan Z.C., Salisbury J.L., Kumar R.J. Biol. Chem. 281:18746-18752(2006) Structural, thermodynamic, and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein.Charbonnier J.B., Renaud E., Miron S., Le Du M.H., Blouquit Y., Duchambon P., Christova P., Shosheva A., Rose T., Angulo J.F., Craescu C.T.J. Mol. Biol. 373:1032-1046(2007) A summary of mutations in the UV-sensitive disordersxeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.Cleaver J.E., Thompson L.H., Richardson A.S., States J.C.3.0.CO;2-6>Hum. Mutat. 14:9-22(1999) Characterization of molecular defects in Xeroderma pigmentosum group C.Li L., Bales E.S., Peterson C.A., Legerski R.J.Nat. Genet. 5:413-417(1993) Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.Chavanne F., Broughton B.C., Pietra D., Nardo T., Browitt A., Lehmann A.R., Stefanini M.Cancer Res. 60:1974-1982(2000) Additional computationally mapped references.Provides general information on the entry. |
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