Recombinant Mouse Adiponectin from MYBIOSOURCE INC.
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| Product Name | Recombinant Mouse Adiponectin |
| Description | Sequence: 18-247aa; Full Length. Purity >90% as determined by SDS-PAGE. Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding af. MW: 29kD |
| Size | 0.01 mg, 0.05 mg, 0.1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | [30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ], [Adipoq; Adipoq; Ad; APN; Acdc; apM1; 30kDa; GBP28; adipo; Acrp30; Acdc; Acrp30; Apm1; ACRP30] |
| Gene, Accession, CAS # | Gene ID: 11450, NCBI: NP_033735.3, UniProt: Q60994 |
| Catalog # | MBS718232 |
| Price | $200, $260, $430 |
| Order / More Info | Recombinant Mouse Adiponectin from MYBIOSOURCE INC. |
| Product Specific References | A novel serum protein similar to C1q, produced exclusively in adipocytes.Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F.J. Biol. Chem. 270:26746-26749(1995) AdipoQ is a novel adipose-specific gene dysregulated in obesity.Hu E., Liang P., Spiegelman B.M.J. Biol. Chem. 271:10697-10703(1996) Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein Acrp30.Das K., Lin Y., Widen E., Zhang Y., Scherer P.E.Biochem. Biophys. Res. Commun. 280:1120-1129(2001) Cloning of murine adipocyte complement-related protein of 30 KDa from white adipose tissue.Wang S.F., Han P.Z., Mu C.J., Zhao M.H. Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity.Wang Y., Xu A., Knight C., Xu L.Y., Cooper G.J.S.J. Biol. Chem. 277:19521-19529(2002) Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q.Sato C., Yasukawa Z., Honda N., Matsuda T., Kitajima K.J. Biol. Chem. 276:28849-28856(2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., Ezaki O., Akanuma Y., Gavrilova O., Vinson C., Reitman M.L., Kagechika H., Shudo K., Yoda M., Nakano Y., Tobe K., Nagai R., Kimura S., Tomita M., Froguel P., Kadowaki T.Nat. Med. 7:941-946(2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.Berg A.H., Combs T.P., Du X., Brownlee M., Scherer P.E.Nat. Med. 7:947-953(2001) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.Xu A., Wang Y., Keshaw H., Xu L.Y., Lam K.S.L., Cooper G.J.S.J. Clin. Invest. 112:91-100(2003) Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes.Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J., Chen B., Lam M.C., Tse C., Cooper G.J.S., Lam K.S.L.J. Biol. Chem. 280:18073-18080(2005) Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner.Wang Y., Lam K.S.L., Xu J.Y., Lu G., Xu L.Y., Cooper G.J.S., Xu A.J. Biol. Chem. 280:18341-18347(2005) Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex.Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam M.C., Hoo R.C.L., Mak W.W.N., Cooper G.J.S., Xu A.J. Biol. Chem. 281:16391-16400(2006) Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin.Wong G.W., Krawczyk S.A., Kitidis-Mitrokostas C., Ge G., Spooner E., Hug C., Gimeno R., Lodish H.F.FASEB J. 23:241-258(2009) Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation.Richards A.A., Colgrave M.L., Zhang J., Webster J., Simpson F., Preston E., Wilks D., Hoehn K.L., Stephenson M., Macdonald G.A., Prins J.B., Cooney G.J., Xu A., Whitehead J.P.Mol. Endocrinol. 24:229-239(2010) The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor.Shapiro L., Scherer P.E.Curr. Biol. 8:335-338(1998) |
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