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Product Name | Recombinant human IL-4I1 protein |
Description | Domain: 22-567aa. Recombinant human IL-4I1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. MW: 61.8kDa (555aa). Purity > 90% by SDS-PAGE. IL-4I1, also known as FIG1, is a secreted L-amino-acid oxidase that acts as a key immunoregulator. It is highly expressed in primary metastinal B-cell lymphomas. This protein acts as a negative regultaotr of anti-tumor immunity by mediating Trp degradation via ans indole pyruvate pathway that activates the transcription factor AHR. IL-4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. IL-41I also regulates M2 macrophage polarization by inhibiting T-cell activation and has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4+ and H2O2 |
Size | 10ug, 20ug, 50ug, 100ug, 250ug, 500ug, 1mg |
Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
Applications | SDS-PAGE, Enzyme Activity |
Other Names | Interleukin 4 induced 1, FIG1, LAAO, LAO, L-amino-acid oxidase isoform 1, L-amino-acid oxidase, IL4-induced protein 1, Fig-1, IL4I1, hIL4I1 |
Gene, Accession, CAS # | NCBI: NP_690863, UniProt: Q96RQ9 |
Catalog # | ATGP4099 |
Price | $160, $280, $460, $770, $1340, $2300, $3840 |
Order / More Info | Recombinant human IL-4I1 protein from NKMAX Co. Ltd. |
Product Specific References | n/a |