Recombinant human IL-2 (C145S) protein from NKMAX Co. Ltd.
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| Product Name | Recombinant human IL-2 (C145S) protein |
| Description | Domain: 22-153aa. Recombinant human IL-2 was overexpressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. MW: 15.4 kDa (133aa) confirmed by MALDI-TOF. Purity > 95% by SDS-PAGE. IL-2, also known as T cell growth factor (TCGF), is an immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. This recombinant human IL-2 is a 15. 4 kDa protein, containing 133 amino acid residues including one intra chain disulfide bond |
| Size | 20ug, 100ug, 500ug |
| Concentration | 0.5mg/ml (determined by Bradford assay) |
| Applications | SDS-PAGE, Bioactivity |
| Other Names | IL-2, TCGF, Aldesleukin, T-cell growth factor, Interleukin-2 |
| Gene, Accession, CAS # | NCBI: NP_000577.2, UniProt: P60568 |
| Catalog # | ILB0501 |
| Price | $105, $320, $960 |
| Order / More Info | Recombinant human IL-2 (C145S) protein from NKMAX Co. Ltd. |
| Product Specific References | Kim HR, et al. Anti-cancer activity and mechanistic features of a NK cell activating molecule. (Cancer Immunol Immunother. 2009){https://pubmed.ncbi.nlm.nih.gov/19259669/};;Koh J, et al. Susceptibility of CD24(+) ovarian cancer cells to anti-cancer drugs and natural killer cells. 9Biochem Biophys Res Commun. 2012){https://pubmed.ncbi.nlm.nih.gov/22995296/};;Lee HM, et al. A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta. (Cell Immunol. 2014){https://pubmed.ncbi.nlm.nih.gov/24879062/};;Shin HW, et al. Role of c-Myb in the regulation of natural killer cell activity. (Biochem Biophys Res Commun. 2018){https://pubmed.ncbi.nlm.nih.gov/30103947/};;Lee Y, et al. In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation. (J Innate Immun. 2020){https://pubmed.ncbi.nlm.nih.gov/32937636/};;Lee YJ, et al. Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. (Int J Mol Sci. 2020){https://pubmed.ncbi.nlm.nih.gov/33339133/};; Ko EH, et al. ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4. (Research Square. 2023){https://doi.org/10.21203/rs.3.rs-2843816/v1} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
6F, SNUH Health Care Innovation Park
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do 13605 REPUBLIC OF KOREA
P: +82-31-8017-8114
F: +82-31-8017-8124
salesbio@nkmax.com
http://www.nkmaxbio.com
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