Recombinant human Sirtuin 3/SIRT3 protein from NKMAX Co. Ltd.
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| Product Name | Recombinant human Sirtuin 3/SIRT3 protein |
| Description | Domain: 118-399aa. Recombinant human SIRT3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 33.5 kDa (303aa) confirmed by MALDI-TOF. Purity > 95% by SDS-PAGE. NAD-dependent deacetylase sirtuin-3, mitochondrial, also known as SIRT3, belongs to the sirtuin family of proteins. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have a range of molecular functions and have emerged as important proteins in aging, stress resistance and metabolic regulation. SIRT3 exhibits NAD+-dependent deacetylase activity in the mitochondria. Over-expression of SIRT3 results in increased levels of the mitochondrial uncoupling protein 1. SIRT3 protein levels are also elevated in certain breast cancers |
| Size | 10ug, 50ug, 250ug |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Applications | SDS-PAGE |
| Other Names | NAD-dependent protein deacetylase sirtuin-3 mitochondrial, hSIRT3, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, SIR2L3 |
| Gene, Accession, CAS # | NCBI: NP_036371.1, UniProt: Q9NTG7 |
| Catalog # | ATGP0650 |
| Price | $80, $240, $720 |
| Order / More Info | Recombinant human Sirtuin 3/SIRT3 protein from NKMAX Co. Ltd. |
| Product Specific References | Kawaguchi M, et al. Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin. (J Med Chem. 2019){https://pubmed.ncbi.nlm.nih.gov/31117516/};;Kawaguchi M, et al. A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of the Dabcyl Quencher. (Chembiochem. 2016){https://pubmed.ncbi.nlm.nih.gov/27542094/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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