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Product Name | Recombinant human Siglec-3/CD33 protein |
Description | Domain: 18-259aa. Recombinant human CD33, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. MW: 54 kDa (484aa). Purity > 90% by SDS-PAGE. CD33, also known as myeloid cell surface antigen CD33 isoform 1, is a member of the Ig superfamily that is restricted to cells of the myelomonocytic lineage but whose functions and binding properties are unknown. It can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when it is expressed in a plasma membrane. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity. It has been identified to modulate the risk of Alzheimer's disease (AD) in several recent genome-wide association studies (GWAS) in Caucasians |
Size | 10ug, 50ug, 250ug |
Concentration | 0.25mg/ml (determined by absorbance at 280nm) |
Applications | SDS-PAGE |
Other Names | SIGLEC-3, SIGLEC3, Sialic acid-binding Ig-like lectin 3, p67, Myeloid cell surface antigen CD33 isoform 1, Myeloid cell surface antigen CD33, FLJ00391, CD33 molecule, CD33 |
Gene, Accession, CAS # | NCBI: NP_001763, UniProt: P20138 |
Catalog # | ATGP3687 |
Price | $105, $320, $1280 |
Order / More Info | Recombinant human Siglec-3/CD33 protein from NKMAX Co. Ltd. |
Product Specific References | n/a |