Edit |   |
Product Name | Recombinant human IL-6R alpha/IL6R protein |
Description | Domain: 20-365aa. Recombinant human IL-6R alpha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. MW: 39.6 kDa (355aa). Purity > 90% by SDS-PAGE. IL-6R alpha, also known as interleukin-6 receptor subunit alpha isoform 1, is a type I cytokine receptor. It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. It has a modular build of several immunoglobulin-like and fibronectin type III-like domains. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. It is implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer |
Size | 10ug, 20ug, 50ug, 100ug, 250ug, 500ug, 1mg |
Concentration | 0.25mg/ml (determined by absorbance at 280nm) |
Applications | SDS-PAGE, Bioactivity |
Other Names | Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R 1, Membrane glycoprotein 80, gp80, CD126 |
Gene, Accession, CAS # | NCBI: NP_000556, UniProt: P08887 |
Catalog # | ATGP3919 |
Price | $140, $250, $400, $670, $1180, $2020, $3360 |
Order / More Info | Recombinant human IL-6R alpha/IL6R protein from NKMAX Co. Ltd. |
Product Specific References | n/a |