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Product Name | Recombinant human IL-21 protein |
Description | Domain: 30-162aa. Recombinant human IL21, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. MW: 16.9 kDa (145aa). Purity > 85% by SDS-PAGE. IL21, also known as interleukin-21 isoform 1, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cells, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate Janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells |
Size | 10ug, 20ug, 50ug, 100ug, 250ug, 500ug, 1mg |
Concentration | 0.25mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE, Bioactivity |
Other Names | Interleukin-21 isoform 1, IL21, CVID11, IL-21, Za11 |
Gene, Accession, CAS # | NCBI: NP_068575, UniProt: Q9HBE4 |
Catalog # | ATGP3802 |
Price | $150, $260, $430, $720, $1260, $2160, $3600 |
Order / More Info | Recombinant human IL-21 protein from NKMAX Co. Ltd. |
Product Specific References | Park SJ, et al. A general toxicity and biodistribution study of human natural killer cells by single or repeated intravenous dose in severe combined immune deficient mice. (Toxicol Res. 2022){https://doi.org/10.1007/s43188-022-00138-0} |