Edit |   |
---|---|
Product Name | Recombinant human IL-15 protein |
Description | Domain: 49-162 aa. Recombinant human IL-15 was expressed in E. coli and purified by using conventional chromatography after refolding of the isolated inclusion bodies in a redox buffer. MW: 13.9 kDa (123aa) confirmed by MALDI-TOF. Purity > 95% by SDS-PAGE. Interleukin (IL) -15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans signaling mechanism in which IL-15 receptor alpha (IL-15R alpha) from one subset of cells presents IL-15 to neighboring IL-2R beta/gamma (c) -expressing cells. This newly discovered cytokine is produced by a wide variety of cells and tissues and like IL-2, stimulates the proliferation of T-lymphocytes and induces the generation of cytotoxic T-lymphocytes (CTLs) and lymphokine-activated killer (LAK) cells |
Size | 10ug, 20ug, 50ug, 100ug, 250ug, 500ug, 1mg |
Concentration | 1mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE, Bioactivity |
Other Names | Interleukin-15 |
Gene, Accession, CAS # | NCBI: NP_751914.1, UniProt: P40933 |
Catalog # | ATGP3844 |
Price | $150, $270, $370, $610, $1060, $1830, $3040 |
Order / More Info | Recombinant human IL-15 protein from NKMAX Co. Ltd. |
Product Specific References | Kim HR, et al. Anti-cancer activity and mechanistic features of a NK cell activating molecule. (Cancer Immunol Immunother. 2009){https://pubmed.ncbi.nlm.nih.gov/19259669/};;Yoon JC, et al. Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells. (J Virol. 2011){https://pubmed.ncbi.nlm.nih.gov/21937646/} |