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Product Name | Recombinant human IL-33 protein |
Description | Domain: 112-270aa. Recombinant human IL-33(C-terminal fragment) was expressed in E.coli and purified by using conventional chromatography techniques. MW: 18.1 kDa (160aa) confirmed by MALDI-TOF. Purity > 95% by SDS-PAGE. Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1 |
Size | 10ug, 20ug, 50ug, 100ug, 250ug, 500ug, 1mg |
Concentration | 1mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE, Bioactivity |
Other Names | Interleukin-33, Interleukin-1 family member 11, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV, DVS27-related protein, DVS27, C9orf26 |
Gene, Accession, CAS # | NCBI: NP_254274, UniProt: O95760 |
Catalog # | ILC0701 |
Price | $100, $160, $290, $480, $920, $1440, $2500 |
Order / More Info | Recombinant human IL-33 protein from NKMAX Co. Ltd. |
Product Specific References | Ito R, et al. A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis. (JCI Insight. 2018){https://pubmed.ncbi.nlm.nih.gov/30385714/} |