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Product Name | Recombinant human Siglec-10 protein |
Description | Domain: 17-455aa. Recombinant human Siglec-10, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. MW: 75.6 kDa (678aa). Purity > 85% by SDS-PAGE. Siglec-10, also known as Sialic acid binding Ig like lectin 10 isoform 3, is a member of the immunoglobulin superfamily that is expressed on eosinophils, neutrophils, monocytes, and B cells. This protein bears an Immuno-receptor tyrosine based inhibitory motif within its cytoplasmic domain. It is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. Also, it binds to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules on the same cell |
Size | 10ug, 50ug, 100ug |
Concentration | 0.25mg/ml (determined by absorbance at 280nm) |
Applications | SDS-PAGE |
Other Names | SIGLEC10, PRO940, SLG2, SIGLEC-10, Sialic acid-binding Ig-like lectin 10 isoform 3, Siglec-like protein 2 |
Gene, Accession, CAS # | NCBI: NP_001164628, UniProt: Q96LC7 |
Catalog # | ATGP3872 |
Price | $140, $330, $550 |
Order / More Info | Recombinant human Siglec-10 protein from NKMAX Co. Ltd. |
Product Specific References | n/a |