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Product Name | Mitochondrial Glycerol-3-Phosphate Dehydrogenase (mGPD) |
Description | Purity >95% by SDS-PAGE. Mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) is a Ca2+ -sensitive, FAD-binding protein, located on the outer surface of the inner mitochondrial membrane. mGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mGPD. Isoform 1 comprises 727aa residues, whereas isoform 2 lacks 126aa residues of the N-terminus. Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin dependent diabetes mellitus |
Size | 1mg |
Concentration | n/a |
Applications | RUO |
Other Names | Recombinant protein. Glycerol-3-Phosphate Dehydrogenase 2, GPD2, Glycerophosphate Dehydrognase-2 Ca(2+ ) - Responsive Mitochondrial FAD-Linked, Mitochondrial GPD, GPDM, GPD-M, GPDH-M, mtGPD, GDH2. |
Gene, Accession, CAS # | n/a |
Catalog # | RCP9303 |
Price | $2294 |
Order / More Info | Mitochondrial Glycerol-3-Phosphate Dehydrogenase (mGPD) from RANDOX LABORATORIES LTD. |
Product Specific References | Brown, L.J. et al., Gene 1996 172 (2) : 309-12. Ferrer J. et al., Diabetes 1996 45 (2) : 262-9 |