Description | Specificity: Natural and recombinant mouse MBL2. There is no detectable cross-reactivity with other relevant proteins. MBL2, also called mannose-binding lectin (protein C) 2, soluble or Mannose-binding lectin (MBL) is a lectin that is instrumental in innate immunity. MBL2 is mapped to chromosome 10q11.2-q21. It belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL2 recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. Binding MBL2 to a micro-organism results in activation of the lectin pathway of the complement system. Another important function of MBL2 is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes. |
Other Names | COLEC1, Collectin-1, Lectin mannose-binding soluble 2, Mannan binding lectin, Mannan binding protein, Mannose binding lectin 2 soluble, Mannose binding lectin 2 soluble, Mannose binding lectin, Mannose binding lectin protein C2 soluble opsonic defect, Mannose binding protein, Mannose binding protein C, Mannose binding protein C precursor, Mannose-binding lectin, MBL, MBL2_HUMAN, MBL2D, MBP 1, MBP, MBP1, MBPB, MBPC, MBPD, Opsonic defect, protein C, Soluble mannose binding lectin |