Human Caspase 8 ELISA Kit from ROCKLAND IMMUNOCHEMICALS INC.
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| Product Name | Human Caspase 8 ELISA Kit |
| Description | Specificity: Natural and recombinant human Caspase 8. There is no detectable cross-reactivity with other relevant proteins. Caspase-8 is a caspase protein, encoded by the CASP8 gene. It is mapped to human chromosome 2q33-q34 and mouse chromosome 1B-proximal C. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. And this protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. |
| Size | 1 kit |
| Concentration | n/a |
| Applications | ELISA |
| Other Names | CASP-8, CASP8, CASP 8, Caspase-8, Caspase8, Caspase 8, MACH, MCH5, MCH 5, CAP 4, CAP4, CAP-4, FADD Like ICE |
| Gene, Accession, CAS # | CASP8, Gene ID: 841, NCBI: NP_001073593.1, UniProt: Q14790 |
| Catalog # | KOA0861 |
| Price | $789 |
| Order / More Info | Human Caspase 8 ELISA Kit from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.