Major Histocompatibility Complex, Class II, DR Beta 3 (HLA-DRB3) Antibody from ABBEXA LTD
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| Antigenic Specificity | Major Histocompatibility Complex, Class II, DR Beta 3 (HLA-DRB3) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-DRB3 antibody is a Rabbit polyclonal antibody against HLA-DRB3. HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]. |
| Immunogen | Recombinant protein of human HLA-DRB3. |
| Other Names | HLA-DR3B, MGC117330, HLA-DR3B, HLA-DR3B, HLA-DR3B , HLA-DR3B , MGC117330, MGC117330, MGC117330 , MGC117330 |
| Gene, Accession # | HLA-DRB3, Gene ID: 3125, UniProt: P79483 |
| Catalog # | abx001355 |
| Price | please inquire |
| Order / More Info | Major Histocompatibility Complex, Class II, DR Beta 3 (HLA-DRB3) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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