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Antigenic Specificity | Kinase D-Interacting Substrate of 220 kDa (KIDINS220) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
Immunogen | KLH-conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220. |
Other Names | ARMS, KIDINS220, KIAA1250, Kinase D-interacting substrate of 220 kDa, Ankyrin repeat-rich membrane-spanning protein, ARMS, ARMS, ARMS , ARMS , KIDINS220, KIDINS220, KIDINS220 , KIDINS220 , KIAA1250, KIAA1250, KIAA1250 , KIAA1250 , Kinase D-interacting substrate of 220 kDa, Kinase D-interacting substrate of 220 kDa, Kinase D-interacting substrate of 220 kDa , Kinase D-interacting substrate of 220 kDa , Ankyrin repeat-rich membrane-spanning protein, Ankyrin repeat-rich membrane-spanning protein, Ankyrin repeat-rich membrane-spanning protein , Ankyrin repeat-rich membrane-spanning protein |
Gene, Accession # | KIDINS220, UniProt: Q9ULH0 |
Catalog # | abx028694 |
Price | please inquire |
Order / More Info | Kinase D-Interacting Substrate of 220 kDa (KIDINS220) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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