Neprilysin / NEP (MME) Antibody from ABBEXA LTD

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Antigenic SpecificityNeprilysin / NEP (MME)
Clonemonoclonal
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatascites
Size100 µl,
Concentrationn/a
ApplicationsELISA, WB, IHC
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DescriptionCD10 (MME): membrane metallo-endopeptidase.This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL.This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues.It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb.The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.The coding region is not affected by alternative splicing.
ImmunogenPurified recombinant fragment of CD10 expressed in E. coli.
Other NamesMME, Membrane Metalloendopeptidase, Common Acute Lymphoblastic Leukemia Antigen, Neutral Endopeptidase 24.11, Skin Fibroblast Elastase, Neutral Endopeptidase, Atriopeptidase, Enkephalinase, Neprilysin, CALLA, NEP, SFE, Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10), Membrane Metallo-Endopeptidase Variant 1, Membrane Metallo-Endopeptidase Variant 2, Neprilysin-390, Neprilysin-411, CD10 Antigen, EC 3.4.24.11, CMT2T, SCA43, CD10, EPN, MME, MME, MME , MME , Membrane Metalloendopeptidase, Membrane Metalloendopeptidase, Membrane Metalloendopeptidase , Membrane Metalloendopeptidase , Common Acute Lymphoblastic Leukemia Antigen, Common Acute Lymphoblastic Leukemia Antigen, Common Acute Lymphoblastic Leukemia Antigen , Common Acute Lymphoblastic Leukemia Antigen , Neutral Endopeptidase 24.11, Neutral Endopeptidase 24.11, Neutral Endopeptidase 24.11 , Neutral Endopeptidase 24.11 , Skin Fibroblast Elastase, Skin Fibroblast Elastase, Skin Fibroblast Elastas
Gene, Accession #MME, Gene ID: 4311, UniProt: P08473
Catalog #abx015726
Priceplease inquire
Order / More InfoNeprilysin / NEP (MME) Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950

Customer Service: info@abbexa.com
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U.S. Office
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Telephone: +44 (0) 1223 755950


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