Cysteine Protease ATG4A (ATG4A) Antibody from ABBEXA LTD
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| Antigenic Specificity | Cysteine Protease ATG4A (ATG4A) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE) conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. |
| Immunogen | KLH-conjugated synthetic peptide between 82-111 amino acids from human ATG4A. |
| Other Names | APG4A, AUTL2, ATG4A, Cysteine protease ATG4A, AUT-like 2 cysteine endopeptidase, Autophagin-2, Autophagy-related cysteine endopeptidase 2, Autophagy-related protein 4 homolog A, ATG4 autophagy related 4 homolog A (S. cerevisiae), APG4 autophagy 4 homolog A, AUT-like 2, cysteine endopeptidase, OTTHUMP00000062893, autophagin 2, HAPG4A, APG4A, APG4A, APG4A , APG4A , AUTL2, AUTL2, AUTL2 , AUTL2 , ATG4A, ATG4A, ATG4A , ATG4A , Cysteine protease ATG4A, Cysteine protease ATG4A, Cysteine protease ATG4A , Cysteine protease ATG4A , AUT-like 2 cysteine endopeptidase, AUT-like 2 cysteine endopeptidase, AUT-like 2 cysteine endopeptidase , AUT-like 2 cysteine endopeptidase , Autophagin-2, Autophagin-2, Autophagin-2 , Autophagin-2 , Autophagy-related cysteine endopeptidase 2, Autophagy-related cysteine endopeptidase 2, Autophagy-related cysteine endopeptidase 2 , Autophagy-related cysteine endopeptidase 2 , Autophagy-related protein 4 homolog A, Autophagy-related protein 4 homolog A, Autophag |
| Gene, Accession # | NCBI: NP_443168.2, NP_840054.1, UniProt: Q8WYN0 |
| Catalog # | abx030003 |
| Price | please inquire |
| Order / More Info | Cysteine Protease ATG4A (ATG4A) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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