INSR (pY1150) / IGF1R (pY1135) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-INSR (pY1150) / IGF1R (pY1135) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | INSR (pY1150) / IGF1R (pY1135) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | INSR (pY1150) / IGF1R (pY1135) Antibody is a Rabbit Polyclonal antibody against INSR (pY1150) / IGF1R (pY1135). Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation. |
| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y1189 of human Insulin Receptor beta. |
| Other Names | INSR, HHF5, CD220, Insulin Receptor beta (pY1189), Phospho-INSR-Y1150/IGF1R-Y1135, INSR, INSR, INSR, INSR, HHF5, HHF5, HHF5, HHF5, CD220, CD220, CD220, CD220, Insulin Receptor beta (pY1189), Insulin Receptor beta (pY1189), Insulin Receptor beta (pY1189), Insulin Receptor beta (pY1189), Phospho-INSR-Y1150/IGF1R-Y1135, Phospho-INSR-Y1150/IGF1R-Y1135, Phospho-INSR-Y1150/IGF1R-Y1135, Phospho-INSR-Y1150/IGF1R-Y1135 |
| Gene, Accession # | INSR, IGF1R, Gene ID: 3643, UniProt: P06213 |
| Catalog # | abx000129 |
| Price | please inquire |
| Order / More Info | INSR (pY1150) / IGF1R (pY1135) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies