Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Toll Like Receptor Adaptor Molecule 1 (TICAM1) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Toll Like Receptor Adaptor Molecule 1 (TICAM1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TICAM1 antibody is a Rabbit polyclonal antibody against TICAM1. Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responsesTLRs recognize conserved motifs found in various pathogens and mediate defense responsesTriggering of the TLR pathway leads to the activation of NF-?B and subsequent regulation of immune and inflammatory genesThe TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domainUpon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule)This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKKActivation of IKK leads to the degradation of I?B that normally maintains NF-?B inactivity by sequestering it in the cytoplasmTRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-?B, IRF3 and trigger IFN-? productionStudies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectivelyTRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-?B activationIn addition, TRIF can trigger signaling of that lead to the induction of apoptosis. |
| Immunogen | Recombinant protein of human TICAM1. |
| Other Names | TICAM1, PRVTIRB, TRIF, TIR domain-containing adapter molecule 1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, TICAM-1, TICAM1, TICAM1, TICAM1 , TICAM1 , PRVTIRB, PRVTIRB, PRVTIRB , PRVTIRB , TRIF, TRIF, TRIF , TRIF , TIR domain-containing adapter molecule 1, TIR domain-containing adapter molecule 1, TIR domain-containing adapter molecule 1 , TIR domain-containing adapter molecule 1 , Proline-rich, Proline-rich, Proline-rich , Proline-rich , vinculin and TIR domain-containing protein B, vinculin and TIR domain-containing protein B, vinculin and TIR domain-containing protein B , vinculin and TIR domain-containing protein B , Putative NF-kappa-B-activating protein 502H, Putative NF-kappa-B-activating protein 502H, Putative NF-kappa-B-activating protein 502H , Putative NF-kappa-B-activating protein 502H , Toll-interleukin-1 receptor doma |
| Gene, Accession # | TICAM1, Gene ID: 148022, UniProt: Q8IUC6 |
| Catalog # | abx117043 |
| Price | please inquire |
| Order / More Info | Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies