Mitochondrial Antiviral Signaling Protein (MAVS) Antibody from ABBEXA LTD
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| Antigenic Specificity | Mitochondrial Antiviral Signaling Protein (MAVS) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]). |
| Immunogen | KLH-conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of human MAVS. |
| Other Names | IPS1, KIAA1271, VISA, Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, IPS1, IPS1, IPS1 , IPS1 , KIAA1271, KIAA1271, KIAA1271 , KIAA1271 , VISA, VISA, VISA , VISA , Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein , Mitochondrial antiviral-signaling protein , MAVS, MAVS, MAVS , MAVS , CARD adapter inducing interferon beta, CARD adapter inducing interferon beta, CARD adapter inducing interferon beta , CARD adapter inducing interferon beta , Cardif, Cardif, Cardif , Cardif , Interferon beta promoter stimulator protein 1, Interferon beta promoter stimulator protein 1, Interferon beta promoter stimulator protein 1 , Interferon beta promoter stimulator protein 1 , IPS-1, IPS-1, IPS-1 , IPS-1 , Putative NF-kappa-B-activating prot |
| Gene, Accession # | MAVS, UniProt: Q7Z434 |
| Catalog # | abx027604 |
| Price | please inquire |
| Order / More Info | Mitochondrial Antiviral Signaling Protein (MAVS) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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