Ubiquitin Specific Peptidase 33 (USP33) Antibody from ABBEXA LTD
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| Antigenic Specificity | Ubiquitin Specific Peptidase 33 (USP33) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ubiquitin Specific Peptidase 33 (USP33) antibody is a Rabbit polyclonal antibody for the detection of USP33. Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains. |
| Immunogen | ubiquitin specific peptidase 33 |
| Other Names | Deubiquitinating enzyme 33, hVDU1, KIAA1097, Ubiquitin thiolesterase 33, USP33, VDU1, Deubiquitinating enzyme 33, Deubiquitinating enzyme 33, Deubiquitinating enzyme 33 , Deubiquitinating enzyme 33 , hVDU1, hVDU1, hVDU1 , hVDU1 , KIAA1097, KIAA1097, KIAA1097 , KIAA1097 , Ubiquitin thiolesterase 33, Ubiquitin thiolesterase 33, Ubiquitin thiolesterase 33 , Ubiquitin thiolesterase 33 , USP33, USP33, USP33 , USP33 , VDU1, VDU1, VDU1 , VDU1 |
| Gene, Accession # | USP33, Gene ID: 23032, NCBI: NP_055832.3, NM_015017.4, UniProt: Q8TEY7 |
| Catalog # | abx239865 |
| Price | please inquire |
| Order / More Info | Ubiquitin Specific Peptidase 33 (USP33) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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