RNA Polymerase III Subunit B (POLR3B) Antibody from ABBEXA LTD
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| Antigenic Specificity | RNA Polymerase III Subunit B (POLR3B) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway. |
| Immunogen | KLH-conjugated synthetic peptide between 330-359 amino acids from the N-terminal region of human POLR3B. |
| Other Names | DNA-directed RNA polymerase III subunit RPC2, RNA polymerase III subunit C2, C128, DNA-directed RNA polymerase III 127.6 kDa polypeptide, DNA-directed RNA polymerase III subunit B, POLR3B, DNA-directed RNA polymerase III subunit RPC2, DNA-directed RNA polymerase III subunit RPC2, DNA-directed RNA polymerase III subunit RPC2 , DNA-directed RNA polymerase III subunit RPC2 , RNA polymerase III subunit C2, RNA polymerase III subunit C2, RNA polymerase III subunit C2 , RNA polymerase III subunit C2 , C128, C128, C128 , C128 , DNA-directed RNA polymerase III 127.6 kDa polypeptide, DNA-directed RNA polymerase III 127.6 kDa polypeptide, DNA-directed RNA polymerase III 127.6 kDa polypeptide , DNA-directed RNA polymerase III 127.6 kDa polypeptide , DNA-directed RNA polymerase III subunit B, DNA-directed RNA polymerase III subunit B, DNA-directed RNA polymerase III subunit B , DNA-directed RNA polymerase III subunit B , POLR3B, POLR3B, POLR3B , POLR3B |
| Gene, Accession # | POLR3B, UniProt: Q9NW08 |
| Catalog # | abx027628 |
| Price | please inquire |
| Order / More Info | RNA Polymerase III Subunit B (POLR3B) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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