Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Glycogen Synthase Kinase 3 Beta (GSK3B) antibody, protein, ELISA kits.
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| Antigenic Specificity | Glycogen Synthase Kinase 3 Beta (GSK3B) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, mouse, monkey, rat |
| Isotype | IgG2a |
| Format | ascites |
| Size | 100 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3 beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3 alpha and Ser9 of GSK-3 beta, S6K, RSK, PKA and PKC), dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta catenin, axin, CK1 and the APC complex). |
| Immunogen | Purified recombinant fragment of human GSK3B expressed in E. Coli.;. |
| Other Names | glycogen synthase kinase 3 beta, Glycogen synthase kinase-3 beta, GSK-3 beta, Serine/threonine-protein kinase GSK3B, GSK3B, GSK3, GSK-3beta, GSK3-beta, glycogen synthase kinase 3 beta, glycogen synthase kinase 3 beta, glycogen synthase kinase 3 beta , glycogen synthase kinase 3 beta , Glycogen synthase kinase-3 beta, Glycogen synthase kinase-3 beta, Glycogen synthase kinase-3 beta , Glycogen synthase kinase-3 beta , GSK-3 beta, GSK-3 beta, GSK-3 beta , GSK-3 beta , Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase GSK3B , Serine/threonine-protein kinase GSK3B , GSK3B, GSK3B, GSK3B , GSK3B , GSK3, GSK3, GSK3 , GSK3 , GSK-3beta, GSK-3beta, GSK-3beta , GSK-3beta , GSK3-beta, GSK3-beta, GSK3-beta , GSK3-beta |
| Gene, Accession # | Gene ID: 2932, UniProt: P49841 |
| Catalog # | abx010856 |
| Price | please inquire |
| Order / More Info | Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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