Presenilin 1 (PSEN1) Antibody from ABBEXA LTD
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| Antigenic Specificity | Presenilin 1 (PSEN1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PSEN1 antibody is a Rabbit polyclonal antibody against PSEN1. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. |
| Immunogen | Recombinant protein of human PSEN1. |
| Other Names | AD3, FAD, PS1, PS-1, S182, Presenilin-1, Protein S182, Presenilin-1 NTF subunit, Presenilin-1 CTF subunit, Presenilin-1 C, PSEN1, PSNL1, PS1-CTF12, AD3, AD3, AD3 , AD3 , FAD, FAD, FAD , FAD , PS1, PS1, PS1 , PS1 , PS-1, PS-1, PS-1 , PS-1 , S182, S182, S182 , S182 , Presenilin-1, Presenilin-1, Presenilin-1 , Presenilin-1 , Protein S182, Protein S182, Protein S182 , Protein S182 , Presenilin-1 NTF subunit, Presenilin-1 NTF subunit, Presenilin-1 NTF subunit , Presenilin-1 NTF subunit , Presenilin-1 CTF subunit, Presenilin-1 CTF subunit, Presenilin-1 CTF subunit , Presenilin-1 CTF subunit , Presenilin-1 C, Presenilin-1 C, Presenilin-1 C , Presenilin-1 C , PSEN1, PSEN1, PSEN1 , PSEN1 , PSNL1, PSNL1, PSNL1 , PSNL1 , PS1-CTF12, PS1-CTF12, PS1-CTF12 , PS1-CTF12 |
| Gene, Accession # | PSEN1, Gene ID: 5663, UniProt: P49768 |
| Catalog # | abx001799 |
| Price | please inquire |
| Order / More Info | Presenilin 1 (PSEN1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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