Palmitoyl-Protein Thioesterase 1 (PPT1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Palmitoyl-Protein Thioesterase 1 (PPT1) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Palmitoyl-Protein Thioesterase 1 (PPT1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Palmitoyl-protein thioesterase-1 (PPT1) is a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Mutations in PPT1 have been found to cause the infantile form of neuronal ceroid lipofuscinosis (INCL), and an animal model has been developed.1 The deduced PPT2 protein contains 302 amino acids, including a 27-amino acid leader peptide, a sequence motif characteristic of many thioesterases and lipases, and 5 potential N-linked glycosylation sites.2 PPT2 shares 18% amino acid identity with PPT1. Northern blot analysis detected a predominant 2.0-kb PPT2 transcript in the human tissues examined, with the highest expression in skeletal muscle; variable amounts of 2.8 and 7.0-kb transcripts were also observed. Recombinant PPT2, like PPT1, possesses thioesterase activity and localizes to the lysosome. Since PPT2 could not substitute for PPT1 in correcting the metabolic defect in INCL cells and was unable to remove palmitate groups from palmitoylated proteins that are routinely used as substrates for PPT1it has been postulated that PPT2 possesses a different substrate specificity than PPT1. |
| Immunogen | KLH-conjugated synthetic peptide between 269-300 amino acids from the C-terminal region of human PPT1. |
| Other Names | Palmitoyl-protein thioesterase 1, PPT-1, Palmitoyl-protein hydrolase 1, PPT1, PPT, Palmitoyl-protein hydrolase 2, Palmitoyl-protein hydrolase 3, CLN1, Palmitoyl-protein thioesterase, INCL, Palmitoyl-protein thioesterase 1, Palmitoyl-protein thioesterase 1, Palmitoyl-protein thioesterase 1 , Palmitoyl-protein thioesterase 1 , PPT-1, PPT-1, PPT-1 , PPT-1 , Palmitoyl-protein hydrolase 1, Palmitoyl-protein hydrolase 1, Palmitoyl-protein hydrolase 1 , Palmitoyl-protein hydrolase 1 , PPT1, PPT1, PPT1 , PPT1 , PPT, PPT, PPT , PPT , Palmitoyl-protein hydrolase 2, Palmitoyl-protein hydrolase 2, Palmitoyl-protein hydrolase 2 , Palmitoyl-protein hydrolase 2 , Palmitoyl-protein hydrolase 3, Palmitoyl-protein hydrolase 3, Palmitoyl-protein hydrolase 3 , Palmitoyl-protein hydrolase 3 , CLN1, CLN1, CLN1 , CLN1 , Palmitoyl-protein thioesterase, Palmitoyl-protein thioesterase, Palmitoyl-protein thioesterase , Palmitoyl-protein thioesterase , INCL, INCL, INCL , INCL |
| Gene, Accession # | UniProt: P50897 |
| Catalog # | abx031627 |
| Price | please inquire |
| Order / More Info | Palmitoyl-Protein Thioesterase 1 (PPT1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies