Mouse Prkcb Antibody from ABBEXA LTD
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| Antigenic Specificity | Mouse Prkcb |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-564', 'Ser-649' and 'Ser-657', leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR) dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters. |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse Prkcb. |
| Other Names | Prkcb, Pkcb, Prkcb1, Protein kinase C beta type, Prkcb, Prkcb, Prkcb , Prkcb , Pkcb, Pkcb, Pkcb , Pkcb , Prkcb1, Prkcb1, Prkcb1 , Prkcb1 , Protein kinase C beta type, Protein kinase C beta type, Protein kinase C beta type , Protein kinase C beta type |
| Gene, Accession # | UniProt: P68404 |
| Catalog # | abx028235 |
| Price | please inquire |
| Order / More Info | Mouse Prkcb Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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