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Antigenic Specificity | Keratin, Type I Cytoskeletal 17 (KRT17) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | ascites |
Size | 100 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17.It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages.Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair.May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial ""stem cells"".May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state.Modulates the function of TNF-alpha in the specific context of hair cycling.Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway.Involved in tissue repair. |
Immunogen | Purified recombinant fragment of CK17 expressed in E. coli. |
Other Names | CK-17, CK 17, CK17, Cytokeratin 17, Cytokeratin17, K17, Keratin 17, Keratin type I cytoskeletal 17, Keratin17, KRT 17, KRT17, KRT17 protein, PC, PC2, PCHC1, CK-17, CK-17, CK-17 , CK-17 , CK 17, CK 17, CK 17 , CK 17 , CK17, CK17, CK17 , CK17 , Cytokeratin 17, Cytokeratin 17, Cytokeratin 17 , Cytokeratin 17 , Cytokeratin17, Cytokeratin17, Cytokeratin17 , Cytokeratin17 , K17, K17, K17 , K17 , Keratin 17, Keratin 17, Keratin 17 , Keratin 17 , Keratin type I cytoskeletal 17, Keratin type I cytoskeletal 17, Keratin type I cytoskeletal 17 , Keratin type I cytoskeletal 17 , Keratin17, Keratin17, Keratin17 , Keratin17 , KRT 17, KRT 17, KRT 17 , KRT 17 , KRT17, KRT17, KRT17 , KRT17 , KRT17 protein, KRT17 protein, KRT17 protein , KRT17 protein , PC, PC, PC , PC , PC2, PC2, PC2 , PC2 , PCHC1, PCHC1, PCHC1 , PCHC1 |
Gene, Accession # | KRT17, Gene ID: 3872, UniProt: Q04695 |
Catalog # | abx015731 |
Price | please inquire |
Order / More Info | Keratin, Type I Cytoskeletal 17 (KRT17) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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