TNF alpha Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | TNF alpha |
| Clone | J2D10 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | 200 µg/mL |
| Applications | Cytotoxicity Test, Flow Cytometry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody neutralises HurTNFamediated cytotoxicity of L929 cells and inhibits tumour growth in mice. It protects mice against toxicity of HurTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. Target Information: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]. |
| Immunogen | Recombinant human TNF-alpha |
| Other Names | DIF|TNF-alpha|TNFA|TNFSF2|APC1 protein|TNF|macrophage-derived|monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha|tumor necrosis factor|Tumor Necrosis Factor alpha|TNF alpha|RATTNF|tumor necrosis factor (TNF superfamily|member 2)|TNFalpha|Tnfsf1a|tumor-necrosis factor|cTNF|tumour necrosis factor|tnfa-like|TNF2|lta|tumor necrosis factor b (TNF superfamily, member 2)|tnfb|ATP-binding cassette|sub-family F (GCN20)|member 1|xtnf|tumour necrosis factor alpha|alpha|LOC103694380|TNF-alpha 1|TNF1|tumor necrosis factor a (TNF superfamily, member 2) |
| Gene, Accession # | Gene ID: 7124 |
| Catalog # | ABIN6934902 |
| Price | $274 |
| Order / More Info | TNF alpha Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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