TNF alpha Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | TNF alpha |
| Clone | T 1 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | biotin conjugate |
| Size | 50 µg |
| Concentration | n/a |
| Applications | Blocking Antibody, Flow Cytometry, Immunoassay, Immunoprecipitation, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody reacts with free soluble (17 kDa) and membrane (26 kDa) human TNF-alpha. The antibody inhibits the biological activity of both forms. It does not react with receptor bound TNF-alpha. It can be a useful tool to discriminate between the membrane form of TNF expressed on producer cells and the proteolytically cleaved, soluble TNF-alpha bound to its cognate cell membrane receptors (TNF-RI and TNF-RII). For this purpose we recommend to use this antibody in combination with the anti-TNF-alpha antibody HM2026, which recognizes soluble, membrane and receptor bound TNF-alpha. Target Information: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | DIF|TNF-alpha|TNFA|TNFSF2|APC1 protein|TNF|macrophage-derived|monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha|tumor necrosis factor|Tumor Necrosis Factor alpha|TNF alpha|RATTNF|tumor necrosis factor (TNF superfamily|member 2)|TNFalpha|Tnfsf1a|tumor-necrosis factor|cTNF|tumour necrosis factor|tnfa-like|TNF2|lta|tumor necrosis factor b (TNF superfamily, member 2)|tnfb|ATP-binding cassette|sub-family F (GCN20)|member 1|xtnf|tumour necrosis factor alpha|alpha|LOC103694380|TNF-alpha 1|TNF1|tumor necrosis factor a (TNF superfamily, member 2) |
| Gene, Accession # | Gene ID: 7124 |
| Catalog # | ABIN2191892 |
| Price | $425 |
| Order / More Info | TNF alpha Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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