TNF alpha Antibody from ANTIBODIES-ONLINE GmbH

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Antigenic SpecificityTNF alpha
CloneT1
Host SpeciesMouse
Reactive Specieshuman
Isotypen/a
Formatfluorescein (FITC) conjugate
Size100 µg
Concentrationn/a
ApplicationsFlow Cytometry, Immunoassay, Western Blotting
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DescriptionThe antibody reacts with free soluble (17 kDa) and membrane (26 kDa) human TNF-alpha. The antibody inhibits the biological activity of both forms. It does not react with receptor bound TNF-alpha. It can be a useful tool to discriminate between the membrane form of TNF expressed on producer cells and the proteolytically cleaved, soluble TNF-alpha bound to its cognate cell membrane receptors (TNF-RI and TNF-RII). For this purpose we recommend to use this antibody in combination with the anti-TNF-alpha antibody HM2026, which recognizes soluble, membrane and receptor bound TNF-alpha. Target Information: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].
Immunogenn/a
Other NamesDIF|TNF-alpha|TNFA|TNFSF2|APC1 protein|TNF|macrophage-derived|monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha|tumor necrosis factor|Tumor Necrosis Factor alpha|TNF alpha|RATTNF|tumor necrosis factor (TNF superfamily|member 2)|TNFalpha|Tnfsf1a|tumor-necrosis factor|cTNF|tumour necrosis factor|tnfa-like|TNF2|lta|tumor necrosis factor b (TNF superfamily, member 2)|tnfb|ATP-binding cassette|sub-family F (GCN20)|member 1|xtnf|tumour necrosis factor alpha|alpha|LOC103694380|TNF-alpha 1|TNF1|tumor necrosis factor a (TNF superfamily, member 2)
Gene, Accession #Gene ID: 7124
Catalog #ABIN2191891
Price$655
Order / More InfoTNF alpha Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155

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