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Antigenic Specificity | IL1R2 |
Clone | 6G5 |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 100 µg |
Concentration | n/a |
Applications | Immunoassay |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody reacts specificly with Human IL-1 R II. The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. Target Information: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]. |
Immunogen | n/a |
Other Names | CD121b|CDw121b|IL-1R-2|IL-1RT-2|IL-1RT2|IL1R2c|IL1RB|CD121 antigen-like family member B|IL-1 type II receptor|IL-1R-beta|antigen CDw121b|interleukin 1 receptor type II variant 3|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II|type II interleukin-1 receptor|beta|interleukin 1 receptor type 2|IL1R2|Interleukin 1 Receptor, Type II|Il1r-2|IL-1 receptor beta chain|soluble type II IL-1 receptor|interleukin-like|KK34|interleukin 1 receptor|type II|IL-1R2|IL-1 receptor 2 |
Gene, Accession # | Gene ID: 7850 |
Catalog # | ABIN2191919 |
Price | $627 |
Order / More Info | IL1R2 Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | n/a |