Tamalin/GRASP Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Tamalin/GRASP |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.03 mg/mL |
| Applications | ELISA, Immunoprecipitation, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domain-containing protein that interacts with group 1 metabotropic glutamate receptors (mGluRs). The PDZ domain-containing amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs. The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins. It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.Target Information: This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein. |
| Other Names | GRASP|GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein|general receptor for phosphoinositides 1 associated scaffold protein|Tamalin/GRASP|TAMALIN|GRP1-associated scaffold protein|general receptor for phosphoinositides 1-associated scaffold protein|95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein|Grp1 (general receptor for phosphoinositides)-associated scaffold protein|PSD-95 PDZ domain-containing protein|GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein L homeolog|grasp.L|graspl|zgc:136876|GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein like |
| Gene, Accession # | Gene ID: 56149 |
| Catalog # | ABIN233820 |
| Price | $537 |
| Order / More Info | Tamalin/GRASP Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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