PD-1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | PD-1 |
| Clone | Nivolumab-5C4-B8 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG4 kappa |
| Format | unconjugated |
| Size | 5 mg |
| Concentration | 1 mg/mL |
| Applications | Flow Cytometry, In vivo Studies |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Nivolumab is a humanized IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation S228P for additional stability and reduced variability. Nivolumab Biosimilar uses the same protein sequences as the therapeutic antibody nivolumab. PD-L1 and PD-L2 (B2-DC or CD273, programmed cell death ligand 2) are the two ligands for the receptor PD-1 (CD279, programmed cell death protein 1). Nivolumab blocks PD-1 inhibitory signalling to T-cells. It has a long duration of action as it is administered every 2-4 weeks. Patients should be counselled regarding the risk of immune-mediated adverse effects, infusion-related adverse effects, complications of allogenic hematopoietic stem cell transplants, embryo-fetal toxicity. The ligands PD-L1 and PD-L2 bind to the PD-1 receptor on T-cells, inhibiting the action of these cells. Tumor cells express PD-L1 and PD-L2. Nivolumab binds to PD-1, preventing PD-L1 and PD-L2 from inhibiting the action of T-cells, restoring a patient's tumor-specific T-cell response. Target Information: May have a role in the regulation of spermatogenesis. |
| Immunogen | The anti-human programmed cell death protein 1 (PD-1) monoclonal antibody nivolumab biosimilar was produced in the nivolumab biosimilar CHO stable cell line. |
| Other Names | CD279|PD-1|PD1|SLEB2|hPD-1|hPD-l|programmed cell death protein 1|protein PD-1|programmed cell death 1|PDCD1|programmed death 1|Ly101|Pdc1|mPD-1 |
| Gene, Accession # | Gene ID: 5133 |
| Catalog # | ABIN7208223 |
| Price | $969 |
| Order / More Info | PD-1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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52072 Aachen GERMANY
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