Klra2 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Klra2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Immunofluorescence, Immunohistochemistry (Paraffin-embedded Sections), Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | KLRA2 Antibody: KLRA2 (also known as Ly49B) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA2 is thought to be an inhibitory receptor and associates with the protein tyrosine phosphatases SHP1, SHP2, and SHIP in transfected cells. This antibody is predicted to not cross-react with other LY49 receptors. Target Information: The gene is a member of the large lectin-like type 2 transmembrane receptor family of the natural killer gene complex. The gene is located distantly telomeric to its family's gene cluster on chromosome 6. The gene differs from the other genes in its cluster as its promoter region contains long and short interspersed repetitive elements suggesting a possible rearrangement or gene conversion. It is unknown whether this gene's encoded protein is involved with natural killer cell differentiation as are its other family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]. |
| Immunogen | KLRA2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of mouse KLRA2. The immunogen is located within the last 50 amino acids of KLRA2. |
| Other Names | Klra30|Ly49b|NK cell inhibitory receptor Klra2|T-cell surface glycoprotein Ly-49B|T-cell surface glycoprotein Ly49b|killer cell lectin-like receptor 2|killer cell lectin-like receptor subfamily A member 30|ly-49b|lymphocyte antigen 49b|membrane protein Ly49b|killer cell lectin-like receptor, subfamily A, member 2|Klra2|Ly49i6|Ly49 inhibitory receptor 6 |
| Gene, Accession # | Gene ID: 16633 |
| Catalog # | ABIN6991061 |
| Price | $519 |
| Order / More Info | Klra2 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
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