Occludin Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | Occludin |
| Clone | polyclonal |
| Host Species | Guinea Pig |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Immunofluorescence, Immunohistochemistry (Frozen Sections), Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The polyclonal antibody reacts with human occludin, an integral membrane protein specifically associated with tight junctions. These specialized regions of the plasma membrane prevent the diffusion of dissolved molecules between adjacent epithelial cells, seal off body cavities such as intestine or stomach lumen and prevent the diffusion of membrane proteins and glycolipids between the apical and basolateral regions of the plasma membrane. Occludin is localized at tight junctions of both epithelial and endothelial cells and is highly expressed in kidney and has not been detected in testis. On the cytoplasmic surface of occludin, a domain within the C-terminal 150 residues has been shown to bind directly to the well-characterized tight junction protein zona occludens 1 (ZO-1). The antibody is generated against recombinant human occludin (aa 358-504). The polyclonal anti- human occludin antibody cross reacts with rat, mouse and dog occludin. Target Information: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]. |
| Immunogen | n/a |
| Other Names | AI503564|Ocl|occludin|Ocln|oclnb|occludin b|occludin S homeolog|ocln.S|tight-junction protein|tpmt|thiopurine methyltransferase|occludin-like|wu:fd23h10|wu:fi13c01|zgc:113992|zgc:56359|occludin a|oclna|BLCPMG|tight junction protein occludin |
| Gene, Accession # | Gene ID: 100506658 |
| Catalog # | ABIN2192203 |
| Price | $627 |
| Order / More Info | Occludin Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
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