CD25 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CD25 |
| Clone | BC96 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | PE-Cy7 conjugate |
| Size | 100 tests |
| Concentration | n/a |
| Applications | Flow Cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The BC96 antibody is specific for human CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL- 2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Signaling via CD25 may modulate Th17 and Treg cell differentiation, and has been shown to play a role in the function of den- dritic cells. The BC96 antibody may be used as a marker for expression of CD25 during T and B cell development, on activated mature T and B cells, and for its expression at high levels on natural T regulatory cells (nTreg cells) in the thymus or periphery, and on ""induced"""" peripheral Tregs. This antibody is cross-reactive with CD25 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus. Target Information: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]." |
| Immunogen | n/a |
| Other Names | CD25|IDDM10|IL2R|TCGFR|IL-2 receptor subunit alpha|IL-2-RA|IL-2R subunit alpha|IL2-RA|TAC antigen|interleukin-2 receptor subunit alpha|p55|interleukin 2 receptor subunit alpha|IL2RA|Interleukin 2 Receptor, alpha|IL2RAC|IL-2 receptor alpha subunit|interleukin 2 receptor|alpha chain|interleukin-2 receptor alpha chain|IL-2 alpha receptor|IL2 receptor alpha|interleukin-2 alpha receptor|IL-2RA|interleukin 2 receptor alpha chain|interleukin-2 receptor alpha subunit|IL-2 Receptor alpha chain|alpha|interleukin-2 receptor subunit alpha-like|LOC100222957|Ly-43|IL-2R alpha chain|p55 chain|interleukin 2 receptor, alpha chain|IL-2R alpha|cytokine receptor|CD25 antigen |
| Gene, Accession # | Gene ID: 3559 |
| Catalog # | ABIN7278407 |
| Price | $215 |
| Order / More Info | CD25 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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52072 Aachen GERMANY
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