HYOU1 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | HYOU1 |
| Clone | 6G7-2H5 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | alkaline phosphatase (AP) conjugate |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | Immunocytochemistry, Immunofluorescence, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GRP170, also known as ORP150, is the largest member of glucose-regulated Antibodys, and acts as a human chaperone Antibody. It is thought to play an important role in Antibody folding and secretion in the ER. Suppression of the Antibody is associated with accelerated apoptosis, therefore having an important cryoprotective role in hypoxia-induced cellular pertubation. This cryopotective role has led to an anti-tumor immune response, which will hopefully lead to therapeutic immunizations against cancers (1). GRP170 has also been shown to bind with dendritic cells and provide the danger signals to induce anti-tumor immune responses (2). Target Information: The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. [provided by RefSeq, Oct 2008]. |
| Immunogen | Raised against a synthetic peptide of human GRP170 |
| Other Names | GRP-170|Grp170|HSP12A|ORP-150|ORP150|150 kDa oxygen-regulated protein|170 kDa glucose-regulated protein|glucose-regulated protein 170|hypoxia up-regulated protein 1|oxygen regulated protein (150kD)|hypoxia up-regulated 1|HYOU1|Hypoxia Up Regulated 1|AI415631|CBP-140|Cab140|140 kDa Ca(2+)-binding protein|150-kDa oxygen regulated protein|170 kDa glucose regulated protein GRP170|calcium binding protein 140|calcium binding protein|140 kDa|id:ibd5056|wu:fd14c05|zgc:56019|LOC100380749|hypoxia up-regulated protein 1-like|glucose regulated protein|170 kDa|oxygen regulated protein|150 kDa|hypoxia up-regulated 1 S homeolog|hyou1.S |
| Gene, Accession # | Gene ID: 10525 |
| Catalog # | ABIN2868655 |
| Price | $573 |
| Order / More Info | HYOU1 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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