JNK Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | JNK |
| Clone | R08-6G2 |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | IgG |
| Format | unconjugated |
| Size | 50 µL |
| Concentration | 300 µg/mL |
| Applications | Immunofluorescence, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | AI849689,c Jun N terminal kinase 1,C-JUN kinase 1,c-Jun N-terminal kinase 1,EC 2.7.11.24,JNK 1,JNK,JNK-46,JNK1A2,JNK21B1/2,MAP kinase 8,MAPK 8,mapk8,Mitogen activated protein kinase 8,Mitogen-activated protein kinase 8,MK08,p54 gamma,Prkm8,Protein kinase JNK1,Protein kinase,mitogen-activated,8,SAPK 1,SAPK gamma,SAPK1,Stress-activated protein kinase 1,Stress-activated protein kinase JNK1,MAPK8(Mitogen-activated protein kinase 8) is also named as JNK1,PRKM8,SAPK1,SAPK1C and belongs to the MAP kinase subfamily. MAPK8 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. MAPK8 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73,mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. It has 4 isoforms produced by alternative splicing with the molecular weight of 46 kDa and 48 kDa. This protein can be phosphorylated and this antibody recognizes the 46 kDa and 55 kDa bands in western blot. Target Information: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | JNK|JNK-46|JNK1|JNK1A2|JNK21B12|PRKM8|SAPK1|SAPK1c|JUN N-terminal kinase|MAP kinase 8|c-Jun N-terminal kinase 1|mitogen-activated protein kinase 8 isoform JNK1 alpha1|mitogen-activated protein kinase 8 isoform JNK1 beta2|stress-activated protein kinase 1|stress-activated protein kinase 1c|mitogen-activated protein kinase 8|MAPK8|Stress-activated protein kinase jnk-1|jnk-1|AI849689|JNK1 beta1 protein kinase|MAPK 8|mitogen activated protein kinase 8|protein kinase mitogen-activated 8|stress-activated protein kinase JNK1|SAPK gamma|c-jun NH2-terminal kinase|p54 gamma|BSK|BSKDJNK|CG5680|D-JNK|D-junk|DBSKJNK|DJNK|DJNKsk|DmelCG5680|JNKSAPK|Junk|SAPKa|c-Jun|CG5680-PB|CG5680-PE|CG5680-PF|JUN kinase|Jun NH2-terminal kinase|Jun-N-terminal kinase|Jun-kinase|bsk-PB|bsk-PE|bsk-PF|c-Jun N-terminal kinase|c-Jun aminoterminal kinase|c-Jun-N-terminal kinase|drosophila JNK|basket|janus kinase 1|T10F20.15|Protein kinase superfamily protein|ATMPK8|mitogen-activated protein kinase 8 L homeolog|mapk8.L|zgc:112379|jnk1a-1|mitogen-activated protein kinase 8b|mapk8b|JNKb|LOW QUALITY PROTEIN: mitogen-activated protein kinase 8B-like|MAP kinase 8B|MAPK 8B|Stress-activated protein kinase JNKb|c-Jun N-terminal kinase B|mitogen-activated protein kinase 8B-like|LOC109094263 |
| Gene, Accession # | Gene ID: 26419, 116554 |
| Catalog # | ABIN7384362 |
| Price | $242 |
| Order / More Info | JNK Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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