ATM Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | ATM |
| Clone | polyclonal |
| Host Species | Sheep |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Western Blotting |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ATM, the gene mutated in the hereditary disease ataxia-telangiectasia, codes for a protein kinase that acts as a master regulator of cellular responses to DNA double-strand breaks. ATM is normally inactive and the question of how it is activated in the event of DNA damage (due to ionizing radiation for instance) is central to understanding its function. ATM protein is now shown to be present in undamaged cells as an inactive dimer. Low doses of ionizing radiation, which induce only a few DNA breaks, activate at least half of the total ATM protein present, possibly in response to changes in chromatin structure. The ATM gene encodes a 370-kDa protein that belongs to the phosphoinositide 3-kinase (PI(3)K) superfamily, but which phosphorylates proteins rather than lipids. The 350-amino-acid kinase domain at the carboxy terminus of this large protein is the only segment of ATM with an assigned function. Exposure of cells to IR triggers ATM kinase activity and this function is required for arrests in G1, S and G2 phases of the cell cycle. Several substrates of the ATM kinase participate in these IR-induced cell-cycle arrests. These include p53, Mdm2 and Chk2 in the G1 checkpoint, Nbs1, Brca1, FancD2 and SMC1 in the transient IR-induced S-phase arrest, and Brca1 and hRad17 in the G2/M checkpoint. This antibody is similar to the rabbit host antibody discussed by Bakkenist, C. J. & Kastan, M. B. in Nature 421, 499-506 (2003).Target Information: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]. |
| Immunogen | This antibody was affinity purified from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to a region near serine 1981 of human ATM conjugated to KLH using maleimide. Immunogen Type: Peptide |
| Other Names | AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1|A-T mutated|AT mutated|telomere maintenance 1|homolog|serine-protein kinase ATM|ATM serine/threonine kinase|ATM|Ataxia Telangiectasia Mutated|AI256621|C030026E19Rik|A-T mutated homolog|ataxia telangiectasia gene mutated in human beings|CG6535|DmelCG6535|Tefu|atm efu|dATM|tef|CG6535-PB|ataxia telengiesctasia mutated|ataxia-telangiectasia mutated|drosophila ATM|tefu-PB|telomere fusion|ataxia telangiectasia mutated homolog|ATM (ataxia telangiectasia mutated)|ataxia telangiectasia mutated (includes complementation groups A|C and D)|Xatm|ATM serine/threonine kinase L homeolog|atm.L|chunp9624|ataxia telangiectasia mutated protein|EDI_100660|CpipJ_CPIJ001772|BDBG_08252|PAAG_02532|MCYG_05088|VDBG_06833|serine-protein kinase ATM-like|ataxia telangiectasia mutated (atm)|ACLA_015700|serine/threonine-protein kinase ATM|LOC5565620|MGYG_07634|PGTG_14279 |
| Gene, Accession # | Gene ID: 472 |
| Catalog # | ABIN964571 |
| Price | $537 |
| Order / More Info | ATM Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
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