CD40 Antibody from ANTIBODIES-ONLINE GmbH
Search, find, compare suppliers for anti-CD40 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CD40 |
| Clone | polyclonal |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | biotin conjugate |
| Size | 100 µg |
| Concentration | 0.1 mg/ml ... |
| Applications | Flow Cytometry, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | anti-mouse monoclonal antibody reacts with CD40 which is expressed on B-lymphocytes and on a subset of both CD4 and CD8 T cells in the adult (but not neonatal) spleen. The level of CD40 on B cells is enhanced following activation buy LPS. The interactions of CD40 with its ligand CD40L are responsible for generating humoral responses, germinal center formation, and generating B cell memory. Stimulating cells with immobilized 3/23 mAb increases expression of CD86 (B7.2) on B cells 1,3. Though the 3/23 mAb itself is a weak mitogen, it produces a synergistic proliferative B cell response with IL-4 or with mitogenic antibodies against surface Ig 1,3. Costimulation with 3/23 mAb and IL-4 rescues B cells from apoptosis induced by hypercross-linking of sIgM or sIgD This antibody is suitable for use in flow cytometry. Other applications of this antibody include IHC of acetone- fixed frozen sections Target Information: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. |
| Immunogen | n/a |
| Other Names | Bp50|CDW40|TNFRSF5|p50|B cell surface antigen CD40|B cell-associated molecule|B-cell surface antigen CD40|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|nerve growth factor receptor-related B-lymphocyte activation molecule|tumor necrosis factor receptor superfamily member 5|tumor necrosis factor receptor superfamily|member 5|CD40 molecule|CD40|AI326936|GP39|HIGM1|IGM|IMD3|T-BAM|TRAP|T-cell differentiation antigen|CD40 antigen|TNFSF5|human CD40-homologue|TNF receptor superfamily member 5 |
| Gene, Accession # | Gene ID: 21939 |
| Catalog # | ABIN133942 |
| Price | $181 |
| Order / More Info | CD40 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155
info@antibodies-online.com
Orders: orders@antibodies-online.com
Technical Support: support@antibodies-online.com
https://www.antibodies-online.com
Profile of ANTIBODIES-ONLINE GmbH
Return to Antibodies